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Sensitive

Dementia

near CCDC91 · rs148377161

Where this position leads

Condition: Dementia with Lewy Bodies

rs148377161 Condition: Dementia with Lewy Bodies Dementia with Lewy Bodies Condition rs148377161 rs148377161 near CCDC91

What the study found

Who was studied 424 European ancestry cases, 2,206 European ancestry controls.

The effect Each copy of the T allele carried 3.24 times the odds of Dementia (95% confidence interval 2.16-4.852); p = 1 × 10−8.

How common The T allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 12, band 12p11.22 — between genes, 95.7 kb from CCDC91.

What each result means

C/C No copy of the version the research linked to Dementia. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Dementia. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Dementia. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-Wide Association Study of Incident Dementia in a Community-Based Sample of Older Subjects
Harper JD, Fan KH, Aslam MM, Snitz BE, DeKosky ST, Lopez OL, Feingold E, Kamboh MI
Journal of Alzheimer's disease : JAD · 2022 · PMID 35694926 · open access

Questions about rs148377161

What is rs148377161?

rs148377161 is a single position in the genome, in or near the near CCDC91 gene. Published research associates it with dementia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs148377161 linked to?

On MyGeneLog this position is linked to Dementia with Lewy Bodies. The research behind each link, and its sources, are set out on that condition page.

Does having rs148377161 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs148377161 come from?

GWAS Catalog, Journal of Alzheimer's disease : JAD 2022, PMID:35694926. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Dementia (rs148377161). MyGeneLog™. https://www.mygenelog.com/variants/rs148377161

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