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Who was studied schizophrenia cases and controls (see Ripke, 2014), up to 6,197 European ancestry ASD cases, up to 7,377 European ancestry controls, up to 1,190 ASD cases, up to 1,190 controls.
The effect
Each copy of the A allele carried 1.10 times the odds of Autism spectrum disorder or schizophrenia (95% confidence interval 1.07-1.13); p = 4 × 10−11.
Where it sits Chromosome 6, band 6p21.32 — between genes, 6.8 kb from HLA-DRB6.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Autism spectrum disorder or schizophrenia compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Autism spectrum disorder or schizophrenia.
G/GPublished research associates this genotype with typical/baseline likelihood of Autism spectrum disorder or schizophrenia — no copies of the reported risk allele.
Molecular autism · 2017 · PMID 28540026 · open access
Questions about rs147976543
What is rs147976543?
rs147976543 is a single position in the genome, in or near the HLA-DRB1 gene. Published research associates it with autism spectrum disorder or schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs147976543 linked to?
On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.
Does having rs147976543 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs147976543 come from?
GWAS Catalog, Molecular autism 2017, PMID:28540026. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 110Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0Others0Total1Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Autism spectrum disorder or schizophrenia (rs147976543). MyGeneLog™. https://www.mygenelog.com/variants/rs147976543