Sensitive

Early-stage non-small cell lung cancer in ever-smokers

PLCL1 · rs147599930

Where this position leads

Condition: Lung Cancer

rs147599930 Condition: Lung Cancer Lung Cancer Condition rs147599930 rs147599930 PLCL1

What the study found

Who was studied 3,123 European ancestry individuals; replicated in 678 individuals.

The effect Each copy of the A allele carried 2.90 times the odds of Early-stage non-small cell lung cancer in ever-smokers (95% confidence interval 2.05215032525438-4.09381200617804); p = 2 × 10−9.

Where it sits Chromosome 2, band 2q33.1 — inside PLCL1.

What each result means

A/A Two copies of the version the research linked to Early-stage non-small cell lung cancer in ever-smokers. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Early-stage non-small cell lung cancer in ever-smokers. That is a smaller link than two copies.
C/C No copy of the version the research linked to Early-stage non-small cell lung cancer in ever-smokers. This is the starting point the study compared everyone against.
Source

Questions about rs147599930

What is rs147599930?

rs147599930 is a single position in the genome, in or near the PLCL1 gene. Published research associates it with early-stage non-small cell lung cancer in ever-smokers. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs147599930 linked to?

On MyGeneLog this position is linked to Lung Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs147599930 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs147599930 come from?

GWAS Catalog, Carcinogenesis 2025, PMID:40746155. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Early-stage non-small cell lung cancer in ever-smokers (rs147599930). MyGeneLog™. https://www.mygenelog.com/variants/rs147599930

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