Standard

Height

SYN3 · rs1475978

Where this position leads

Condition: Height

rs1475978 Condition: Height Height Condition rs1475978 rs1475978 SYN3

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−24, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 455,180 Hispanic or Latin American individuals.

The effect Each copy of the G allele shifted the measure 0.0278 lower (95% confidence interval 0.023-0.033); p = 4 × 10−25.

How common The G allele had a frequency of about 22% in the people studied.

Where it sits Chromosome 22, band 22q12.3 — in an intron of SYN3.

What each result means

A/A No copy of the version the research linked to Height. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Height. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Height. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs1475978

What is rs1475978?

rs1475978 is a single position in the genome, in or near the SYN3 gene. Published research associates it with height. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1475978 linked to?

On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.

Does having rs1475978 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1475978 come from?

GWAS Catalog, Nature 2022, PMID:36224396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Height (rs1475978). MyGeneLog™. https://www.mygenelog.com/variants/rs1475978

← See all variants