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Its strongest genetic-study result is p = 10−24, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 455,180 Hispanic or Latin American individuals.
The effect
Each copy of the G allele shifted the measure 0.0278 lower (95% confidence interval 0.023-0.033); p = 4 × 10−25.
How common The G allele had a frequency of about 22% in the people studied.
Where it sits Chromosome 22, band 22q12.3 — in an intron of SYN3.
What each result means
A/ANo copy of the version the research linked to Height. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Height. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Height. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs1475978 is a single position in the genome, in or near the SYN3 gene. Published research associates it with height. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1475978 linked to?
On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.
Does having rs1475978 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1475978 come from?
GWAS Catalog, Nature 2022, PMID:36224396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 17116225Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI1Microsoft · Copilot6Amazon2Apple2China (ByteDance, Huawei, Baidu…)0Others5Total17Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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