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Mitochondrial DNA levels

MFN2 · rs1474868

What the study found

Who was studied 295,150 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0203 lower (95% confidence interval 0.015-0.025); p = 4 × 10−15.

How common The T allele had a frequency of about 47% in the people studied.

Where it sits Chromosome 1, band 1p36.22 — in an intron of MFN2.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Mitochondrial DNA levels — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Mitochondrial DNA levels.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Mitochondrial DNA levels compared to the general population.
Source

Questions about rs1474868

What is rs1474868?

rs1474868 is a single position in the genome, in or near the MFN2 gene. Published research associates it with mitochondrial dna levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1474868 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1474868 come from?

GWAS Catalog, Human genetics 2021, PMID:33385171. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Mitochondrial DNA levels (rs1474868). MyGeneLog™. https://www.mygenelog.com/variants/rs1474868

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