Sensitive

Response to antipsychotic treatment in schizophrenia

SLC1A1 · rs1471786

Where this position leads

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Response to antipsychotic treatment in schizophrenia — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Response to antipsychotic treatment in schizophrenia.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Response to antipsychotic treatment in schizophrenia compared to the general population.

Source

Five novel loci associated with antipsychotic treatment response in patients with schizophrenia: a genome-wide association study

Yu H, Yan H, Wang L, Li J, Tan L, Deng W, Chen Q, Yang G, Zhang F, Lu T, Yang J, Li K

and 12 more — show all

Lv L, Tan Q, Zhang H, Xiao X, Li M, Ma X, Yang F, Li L, Wang C, Li T, Zhang D, Yue W

Chinese Antipsychotics Pharmacogenomics Consortium

The lancet. Psychiatry · 2018 · PMID 29503163

Questions about rs1471786

What is rs1471786?

rs1471786 is a single position in the genome, in or near the SLC1A1 gene. Published research associates it with response to antipsychotic treatment in schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1471786 linked to?

On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.

Does having rs1471786 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1471786 come from?

GWAS Catalog, Lancet Psychiatry 2018, PMID:29503163. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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