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Who was studied 9,219 European ancestry cases, 10,345 European ancestry controls.
The effect
Each copy of the T allele carried 1.06 times the odds of Alzheimer's disease (age of onset) (95% confidence interval 1.04-1.08); p = 1 × 10−8.
How common The T allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 20, band 20q13.13 — in an intron of ARFGEF2.
What each result means
C/CNo copy of the version the research linked to Alzheimer's disease (age of onset). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Alzheimer's disease (age of onset). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Alzheimer's disease (age of onset). That is the strongest link of the three results. A link in a study is not a diagnosis.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023 · PMID 36738287
Questions about rs147145199
What is rs147145199?
rs147145199 is a single position in the genome, in or near the ARFGEF2 gene. Published research associates it with alzheimer's disease (age of onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs147145199 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs147145199 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs147145199 come from?
GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2023, PMID:36738287. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Alzheimer's disease (age of onset) (rs147145199). MyGeneLog™. https://www.mygenelog.com/variants/rs147145199