Sensitive

Alzheimer disease and age of onset

GABRA2 · rs147028191

Where this position leads

Condition: Alzheimer's Disease

rs147028191 Condition: Alzheimer's Disease Alzheimer's Disease Condition rs147028191 rs147028191 GABRA2

What the study found

Who was studied 2,478 European ancestry cases, 979 ancestry controls both from the same 1,070 families.

The effect Each copy of the A allele shifted the measure 6.06 higher (95% confidence interval -); p = 1 × 10−9.

Where it sits Chromosome 4, band 4p12 — in an intron of GABRA2.

What each result means

A/A Two copies of the version the research linked to Alzheimer disease and age of onset. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Alzheimer disease and age of onset. That is a smaller link than two copies.
G/G No copy of the version the research linked to Alzheimer disease and age of onset. This is the starting point the study compared everyone against.
Source

Questions about rs147028191

What is rs147028191?

rs147028191 is a single position in the genome, in or near the GABRA2 gene. Published research associates it with alzheimer disease and age of onset. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs147028191 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs147028191 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs147028191 come from?

GWAS Catalog, Mol Psychiatry 2016, PMID:26830138. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alzheimer disease and age of onset (rs147028191). MyGeneLog™. https://www.mygenelog.com/variants/rs147028191

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