SMAD3 · rs1470002
Where this position leads
Condition: Waist Circumference
What the study found
Who was studied 186,825 British ancestry men.
The effect Each copy of the A allele shifted the measure 0.0201 lower (95% confidence interval 0.014-0.026); p = 3 × 10−10.
Where it sits Chromosome 15, band 15q22.33 — in an intron of SMAD3.
rs1470002 is a single position in the genome, in or near the SMAD3 gene. Published research associates it with waist circumference adjusted for body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Waist Circumference. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Scientific reports 2021, PMID:34021172. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Waist circumference adjusted for body mass index (rs1470002). MyGeneLog™. https://www.mygenelog.com/variants/rs1470002