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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 39,165 European ancestry males.
The effect
Each copy of the G allele shifted the measure 0.386 higher (95% confidence interval 0.26-0.51); p = 7 × 10−10.
How common The G allele had a frequency of about 0% in the people studied.
Where it sits Chromosome X, band Xq12 — inside OPHN1.
What each result means
C/CNo copy of the version the research linked to Estradiol levels. This is the starting point the study compared everyone against.
C/GOne copy of the version the research linked to Estradiol levels. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Estradiol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 40229599 · open access
Questions about rs1469860002
What is rs1469860002?
rs1469860002 is a single position in the genome, in or near the OPHN1 gene. Published research associates it with estradiol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1469860002 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1469860002 come from?
GWAS Catalog, Nature genetics 2025, PMID:40229599. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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