Standard

PR interval

SOX5 · rs146974314

Where this position leads

Condition: Cardiac Conduction Intervals (PR Interval and QRS Duration)

What the study found

Who was studied 14,756 Hispanic individuals; replicated in 4,296 European ancestry individuals, 3,763 African American individuals, 6,805 East Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 2.66 ms lower (95% confidence interval 1.97-3.35); p = 9 × 10⁻¹⁵.

How common The A allele had a frequency of about 14% in the people studied.

Where it sits Chromosome 12, band 12p12.1 — in an intron of LOC105369698.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of PR interval compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with PR interval.

G/G Published research associates this genotype with typical/baseline likelihood of PR interval — no copies of the reported risk allele.

Source

Genome-wide association study of PR interval in Hispanics/Latinos identifies novel locus at <i>ID2</i>

Seyerle AA, Lin HJ, Gogarten SM, Stilp A, Méndez Giráldez R, Soliman E, Baldassari A, Graff M, Heckbert S, Kerr KF, Kooperberg C, Rodriguez C

and 8 more — show all

Guo X, Yao J, Sotoodehnia N, Taylor KD, Whitsel EA, Rotter JI, Laurie CC, Avery CL

Heart (British Cardiac Society) · 2018 · PMID 29127183

Questions about rs146974314

What is rs146974314?

rs146974314 is a single position in the genome, in or near the SOX5 gene. Published research associates it with pr interval. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs146974314 linked to?

On MyGeneLog this position is linked to Cardiac Conduction Intervals (PR Interval and QRS Duration). The research behind each link, and its sources, are set out on that condition page.

Does having rs146974314 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs146974314 come from?

GWAS Catalog, Heart 2017, PMID:29127183. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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PR interval (rs146974314). MyGeneLog™. https://www.mygenelog.com/variants/rs146974314

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