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Who was studied 46,802 European ancestry cases, 347,481 European ancestry controls; replicated in 23,948 European and unknown ancestry cases, 118,538 European and unknown ancestry controls.
The effect
Each copy of the C allele carried 1.18 times the odds of Asthma (95% confidence interval 1.14-1.22); p = 2 × 10−14.
How common The C allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 17, band 17q12 — in an intron of MED1.
What each result means
C/CTwo copies of the version the research linked to Asthma. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Asthma. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Asthma. This is the starting point the study compared everyone against.
The European respiratory journal · 2019 · PMID 31619474
Questions about rs146644295
What is rs146644295?
rs146644295 is a single position in the genome, in or near the ARL5C gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs146644295 linked to?
On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.
Does having rs146644295 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs146644295 come from?
GWAS Catalog, The European respiratory journal 2019, PMID:31619474. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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