Standard

Psoriasis (PheCode 696.4)

TNIP1 · rs146571698

Where this position leads

Condition: Psoriasis

rs146571698 Condition: Psoriasis Psoriasis Condition rs146571698 rs146571698 TNIP1

What the study found

Who was studied 1,711 African American or Afro-Caribbean cases, 119,220 African American or Afro-Caribbean controls, 1,845 Hispanic or Latin American cases, 57,348 Hispanic or Latin American controls, 245 East Asian ancestry cases, 6,518 East Asian ancestry controls, 16,283 European ancestry cases, 428,468 European ancestry controls.

The effect Each copy of the C allele shifted the measure 0.265 lower (95% confidence interval 0.23-0.3); p = 6 × 10−32.

How common The C allele had a frequency of about 95% in the people studied.

Where it sits Chromosome 5, band 5q33.1 — inside TNIP1.

What each result means

C/C Two copies of the version the research linked to Psoriasis (PheCode 696.4). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Psoriasis (PheCode 696.4). That is a smaller link than two copies.
T/T No copy of the version the research linked to Psoriasis (PheCode 696.4). This is the starting point the study compared everyone against.
Source

Questions about rs146571698

What is rs146571698?

rs146571698 is a single position in the genome, in or near the TNIP1 gene. Published research associates it with psoriasis (phecode 696.4). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs146571698 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs146571698 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs146571698 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis (PheCode 696.4) (rs146571698). MyGeneLog™. https://www.mygenelog.com/variants/rs146571698

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