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Atrial fibrillation

MIR6500 · rs146518726

Where this position leads

Condition: Atrial Fibrillation

rs146518726 Condition: Atrial Fibrillation Atrial Fibrillation Condition rs146518726 rs146518726 MIR6500

What the study found

Who was studied 60,620 European ancestry cases, 970,216 European ancestry controls.

The effect Each copy of the A allele carried 1.17 times the odds of Atrial fibrillation (95% confidence interval 1.13-1.22); p = 8 × 10−15.

How common The A allele had a frequency of about 3% in the people studied.

Where it sits Chromosome 1, band 1p32.3 — between genes, 9.3 kb from MIR6500.

What each result means

A/A Two copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
G/G No copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
Source

Questions about rs146518726

What is rs146518726?

rs146518726 is a single position in the genome, in or near the MIR6500 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs146518726 linked to?

On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.

Does having rs146518726 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs146518726 come from?

GWAS Catalog, Nat Genet 2018, PMID:30061737. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Atrial fibrillation (rs146518726). MyGeneLog™. https://www.mygenelog.com/variants/rs146518726

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