AMN · rs146499374
Where this position leads
Condition: Celiac Disease
What the study found
Who was studied 394,642 European ancestry individuals.
The effect Each copy of the G allele shifted the measure 0.0887 higher (95% confidence interval 0.062-0.115); p = 1 × 10−11.
How common The G allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 14, band 14q32.32 — a missense change in AMN.
What ClinVar records
Classification
Benign/Likely benign for Imerslund-Grasbeck syndrome, Imerslund-Grasbeck syndrome type 2; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 6 submitters), last evaluated 2026-01-31.
ClinVar record 463391 NM_030943.4(AMN):c.829A>G (p.Thr277Ala)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs146499374 is a single position in the genome, in or near the AMN gene. Published research associates it with gamma glutamyltransferase levels (ukb data field 30730). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Gamma glutamyltransferase levels (UKB data field 30730) (rs146499374). MyGeneLog™. https://www.mygenelog.com/variants/rs146499374