IGF1R · rs146465276
Where this position leads
Condition: Hand Grip Strength
Strength of the evidence
Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 404,112 European ancestry individuals.
The effect Each copy of the C allele shifted the measure 0.0347 higher (95% confidence interval 0.024-0.046); p = 7 × 10−10.
How common The C allele had a frequency of about 98% in the people studied.
Where it sits Chromosome 15, band 15q26.3 — in an intron of IGF1R.
rs146465276 is a single position in the genome, in or near the IGF1R gene. Published research associates it with hand grip strength (baseline). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Hand Grip Strength. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2025, PMID:40374629. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Hand grip strength (baseline) (rs146465276). MyGeneLog™. https://www.mygenelog.com/variants/rs146465276