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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 594 African American or Afro-Caribbean cases, 119,312 African American or Afro-Caribbean controls, 3,238 European ancestry cases, 438,412 European ancestry controls, 456 Hispanic or Latin American cases, 58,256 Hispanic or Latin American controls.
The effect
Each copy of the G allele shifted the measure 2.28 lower (95% confidence interval 2.23-2.33); p = 4 × 10−11.
How common The G allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 11, band 11q14.1 — in an intron of DLG2.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Disorders of external ear (PheCode 380) — no copies of the reported risk allele.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Disorders of external ear (PheCode 380).
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Disorders of external ear (PheCode 380) compared to the general population.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs146094436
What is rs146094436?
rs146094436 is a single position in the genome, in or near the DLG2 gene. Published research associates it with disorders of external ear (phecode 380). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs146094436 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs146094436 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Disorders of external ear (PheCode 380) (rs146094436). MyGeneLog™. https://www.mygenelog.com/variants/rs146094436