Alzheimer's disease, proxy Alzheimer's disease or related dementias
VMAC · rs146033453
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Who was studied 128,681 European ancestry cases, 849,833 European ancestry controls.
The effect
Each copy of the C allele carried 0.95 times the odds of Alzheimer's disease, proxy Alzheimer's disease or related dementias (95% confidence interval 0.93-0.96); p = 6 × 10−10.
How common The C allele had a frequency of about 14% in the people studied.
Where it sits Chromosome 19, band 19p13.3 — in an intron of VMAC.
What each result means
C/CTwo copies of the version the research linked to Alzheimer's disease, proxy Alzheimer's disease or related dementias. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Alzheimer's disease, proxy Alzheimer's disease or related dementias. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Alzheimer's disease, proxy Alzheimer's disease or related dementias. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 42237039 · open access
Questions about rs146033453
What is rs146033453?
rs146033453 is a single position in the genome, in or near the VMAC gene. Published research associates it with alzheimer's disease, proxy alzheimer's disease or related dementias. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs146033453 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs146033453 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs146033453 come from?
GWAS Catalog, Nature genetics 2026, PMID:42237039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 00Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total0Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Alzheimer's disease, proxy Alzheimer's disease or related dementias (rs146033453). MyGeneLog™. https://www.mygenelog.com/variants/rs146033453