Gene Knowledge Graph
UTC
Standard

Asthma

IL4R · rs145986476

Where this position leads

Condition: Asthma

rs145986476 Condition: Asthma Asthma Condition rs145986476 rs145986476 IL4R

What the study found

Who was studied 394,626 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.346 lower (95% confidence interval 0.25-0.44); p = 8 × 10−14.

How common The A allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 16, band 16p12.1 — in an intron of IL4R.

What each result means

A/A Two copies of the version the research linked to Asthma. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Asthma. That is a smaller link than two copies.
C/C No copy of the version the research linked to Asthma. This is the starting point the study compared everyone against.
Source
A scalable variational inference approach for increased mixed-model association power
Loya H, Kalantzis G, Cooper F, Palamara PF
Nature genetics · 2025 · PMID 39789286 · open access

Questions about rs145986476

What is rs145986476?

rs145986476 is a single position in the genome, in or near the IL4R gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs145986476 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs145986476 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs145986476 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Asthma (rs145986476). MyGeneLog™. https://www.mygenelog.com/variants/rs145986476

← See all variants