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Migraine

PDZRN4 · rs1458170

Where this position leads

Condition: Migraine

rs1458170 Condition: Migraine Migraine Condition rs1458170 rs1458170 PDZRN4

What the study found

Who was studied 102,084 European ancestry cases, 771,257 European ancestry controls.

The effect Each copy of the C allele shifted the measure 1.04 higher (95% confidence interval 1.03-1.06); p = 6 × 10−9.

How common The C allele had a frequency of about 84% in the people studied.

Where it sits Chromosome 12, band 12q12 — in an intron of PDZRN4.

What each result means

C/C Two copies of the version the research linked to Migraine. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Migraine. That is a smaller link than two copies.
T/T No copy of the version the research linked to Migraine. This is the starting point the study compared everyone against.
Source
Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
Hautakangas H, Winsvold BS, Ruotsalainen SE, Bjornsdottir G, Harder AVE, Kogelman LJA, Thomas LF, Noordam R, Benner C, Gormley P, Artto V, Banasik K
and 59 more — show all
Bjornsdottir A, Boomsma DI, Brumpton BM, Burgdorf KS, Buring JE, Chalmer MA, de Boer I, Dichgans M, Erikstrup C, Färkkilä M, Garbrielsen ME, Ghanbari M, Hagen K, Häppölä P, Hottenga JJ, Hrafnsdottir MG, Hveem K, Johnsen MB, Kähönen M, Kristoffersen ES, Kurth T, Lehtimäki T, Lighart L, Magnusson SH, Malik R, Pedersen OB, Pelzer N, Penninx BWJH, Ran C, Ridker PM, Rosendaal FR, Sigurdardottir GR, Skogholt AH, Sveinsson OA, Thorgeirsson TE, Ullum H, Vijfhuizen LS, Widén E, van Dijk KW, Aromaa A, Belin AC, Freilinger T, Ikram MA, Järvelin MR, Raitakari OT, Terwindt GM, Kallela M, Wessman M, Olesen J, Chasman DI, Nyholt DR, Stefánsson H, Stefansson K, van den Maagdenberg AMJM, Hansen TF, Ripatti S, Zwart JA, Palotie A, Pirinen M
International Headache Genetics Consortium · HUNT All-in Headache · Danish Blood Donor Study Genomic Cohort
Nature genetics · 2022 · PMID 35115687 · open access

Questions about rs1458170

What is rs1458170?

rs1458170 is a single position in the genome, in or near the PDZRN4 gene. Published research associates it with migraine. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1458170 linked to?

On MyGeneLog this position is linked to Migraine. The research behind each link, and its sources, are set out on that condition page.

Does having rs1458170 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1458170 come from?

GWAS Catalog, Nature genetics 2022, PMID:35115687. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Migraine (rs1458170). MyGeneLog™. https://www.mygenelog.com/variants/rs1458170

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