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Steroid induced osteonecrosis of the femoral head and systemic lupus erythematosus

MYO16 · rs145720245

Where this position leads

Condition: Systemic Lupus Erythematosus

rs145720245 Condition: Systemic Lupus Erythematosus Systemic Lupus Erythematosus Condition rs145720245 rs145720245 MYO16

What the study found

Who was studied 636 Japanese ancestry cases, 95,588 Japanese ancestry controls.

The effect Each copy of the A allele carried 4.00 times the odds of Steroid induced osteonecrosis of the femoral head and systemic lupus erythematosus (95% confidence interval 2.6-6.15); p = 3 × 10−10.

Where it sits Chromosome 13, band 13q33.3 — in an intron of MYO16.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Steroid induced osteonecrosis of the femoral head and systemic lupus erythematosus compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Steroid induced osteonecrosis of the femoral head and systemic lupus erythematosus.
G/G Published research associates this genotype with typical/baseline likelihood of Steroid induced osteonecrosis of the femoral head and systemic lupus erythematosus — no copies of the reported risk allele.
Source
Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus
Suetsugu H, Kim K, Yamamoto T, Bang SY, Sakamoto Y, Shin JM, Sugano N, Kim JS, Mukai M, Lee YK, Ohmura K, Park DJ
and 43 more — show all
Takahashi D, Ahn GY, Karino K, Kwon YC, Miyamura T, Kim J, Nakamura J, Motomura G, Kuroda T, Niiro H, Miyamoto T, Takeuchi T, Ikari K, Amano K, Tada Y, Yamaji K, Shimizu M, Atsumi T, Seki T, Tanaka Y, Kubo T, Hisada R, Yoshioka T, Yamazaki M, Kabata T, Kajino T, Ohta Y, Okawa T, Naito Y, Kaneuji A, Yasunaga Y, Ohzono K, Tomizuka K, Koido M, Matsuda K, Okada Y, Suzuki A, Kim BJ, Kochi Y, Lee HS, Ikegawa S, Bae SC, Terao C
Human molecular genetics · 2022 · PMID 34850884

Questions about rs145720245

What is rs145720245?

rs145720245 is a single position in the genome, in or near the MYO16 gene. Published research associates it with steroid induced osteonecrosis of the femoral head and systemic lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs145720245 linked to?

On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs145720245 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs145720245 come from?

GWAS Catalog, Human molecular genetics 2022, PMID:34850884. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Steroid induced osteonecrosis of the femoral head and systemic lupus erythematosus (rs145720245). MyGeneLog™. https://www.mygenelog.com/variants/rs145720245

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