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Uterine fibroids

SUFU · rs145635512

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−10, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 53,711 European ancestry female cases, 380,441 European ancestry female controls, 14,905 East Asian ancestry female cases, 69,609 East Asian ancestry female controls, 14,905 Central Asian ancestry female cases, 69,609 Central Asian ancestry female controls, 14,905 South Asian ancestry female cases, 69,609 South Asian ancestry female controls, 5,678 African ancestry female cases, 15,760 African ancestry female controls.

The effect Each copy of the A allele shifted the measure 0.199 higher (95% confidence interval 0.14-0.26); p = 4 × 10−11.

Where it sits Chromosome 10, band 10q24.32 — in an intron of SUFU.

How common each version is

AG
Korean KRGDB
A 0.3% · G 99.7%
Korean Korea4K
A 0.3% · G 99.7%
Korean Korea1K
A 0.4% · G 99.6%
Japanese ToMMo
A 0.1% · G 99.9%
World gnomAD
A 0.5% · G 99.5%
World 1000 Genomes
A 0.4% · G 99.6%
World TOPMed
A 0.5% · G 99.5%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A Two copies of the version the research linked to Uterine fibroids. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Uterine fibroids. That is a smaller link than two copies.
G/G No copy of the version the research linked to Uterine fibroids. This is the starting point the study compared everyone against.
Source
Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups
Kim J, Williams A, Noh H, Jasper EA, Jones SH, Jaworski JA, Shuey MM, Ruiz-Narváez EA, Wise LA, Palmer JR, Connolly J, Keaton JM
and 11 more — show all
Denny JC, Khan A, Abbass MA, Rasmussen-Torvik LJ, Kottyan LC, Madhivanan P, Krupp K, Wei WQ, Edwards TL, Velez Edwards DR, Hellwege JN
Nature communications · 2025 · PMID 40050615 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Uterine fibroids (rs145635512). MyGeneLog™. https://www.mygenelog.com/variants/rs145635512

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