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Hodgkin's lymphoma

PGRMC1 · rs145582672

Where this position leads

Condition: Hodgkin Lymphoma

rs145582672 Condition: Hodgkin Lymphoma Hodgkin Lymphoma Condition rs145582672 rs145582672 PGRMC1

What the study found

Who was studied 56 Greater Middle Eastern ancestry cases, 5 unknown ancestry cases, 36 Greater Middle Eastern ancestry controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 9 × 10−12.

How common The A allele had a frequency of about 48% in the people studied.

Where it sits Chromosome X, band Xq24 — a missense change in PGRMC1.

What each result means

A/A Two copies of the version the research linked to Hodgkin's lymphoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Hodgkin's lymphoma. That is a smaller link than two copies.
G/G No copy of the version the research linked to Hodgkin's lymphoma. This is the starting point the study compared everyone against.
Source

Questions about rs145582672

What is rs145582672?

rs145582672 is a single position in the genome, in or near the PGRMC1 gene. Published research associates it with hodgkin's lymphoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs145582672 linked to?

On MyGeneLog this position is linked to Hodgkin Lymphoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs145582672 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs145582672 come from?

GWAS Catalog, International journal of laboratory hematology 2021, PMID:34216518. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Hodgkin's lymphoma (rs145582672). MyGeneLog™. https://www.mygenelog.com/variants/rs145582672

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