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Who was studied at least 71,880 European ancestry cases, at least 383,378 European ancestry controls (MTAG boosted by 757,601 blood pressure samples).
The effect
Each copy of the C allele shifted the measure 0.0175 lower (95% confidence interval 0.012-0.023); p = 1 × 10−9.
Where it sits Chromosome 2, band 2q33.2 — in an intron of NBEAL1.
What each result means
C/CTwo copies of the version the research linked to Alzheimer's disease (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Alzheimer's disease (MTAG). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Alzheimer's disease (MTAG). This is the starting point the study compared everyone against.
Nature communications · 2024 · PMID 39537608 · open access
Questions about rs145538381
What is rs145538381?
rs145538381 is a single position in the genome, in or near the NBEAL1 gene. Published research associates it with alzheimer's disease (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs145538381 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs145538381 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs145538381 come from?
GWAS Catalog, Nature communications 2024, PMID:39537608. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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