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NRCAM protein levels

near DNAJB9 · rs145468221

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.239 higher (95% confidence interval 0.18-0.29); p = 3 × 10−20.

How common The G allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 7, band 7q31.1 — between genes, 11 kb from DNAJB9.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of NRCAM protein levels — no copies of the reported risk allele.
C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with NRCAM protein levels.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of NRCAM protein levels compared to the general population.
Source

Questions about rs145468221

What is rs145468221?

rs145468221 is a single position in the genome, in or near the near DNAJB9 gene. Published research associates it with nrcam protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs145468221 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs145468221 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

NRCAM protein levels (rs145468221). MyGeneLog™. https://www.mygenelog.com/variants/rs145468221

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