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Alcohol consumption

ADH1B · rs145452708

Where this position leads

Condition: Alcohol Consumption

rs145452708 Condition: Alcohol Consumption Alcohol Consumption Condition rs145452708 rs145452708 ADH1B

What the study found

Who was studied 59,088 European ancestry females, 53,029 European ancestry males.

The effect Each copy of the C allele shifted the measure 0.037 lower (95% confidence interval 0.029-0.045); p = 3 × 10−19.

How common The C allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 4, band 4q23 — between genes, 5.8 kb from ADH1B.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Alcohol consumption compared to the general population.
C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Alcohol consumption.
G/G Published research associates this genotype with typical/baseline likelihood of Alcohol consumption — no copies of the reported risk allele.
Source
Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117)
Clarke TK, Adams MJ, Davies G, Howard DM, Hall LS, Padmanabhan S, Murray AD, Smith BH, Campbell A, Hayward C, Porteous DJ, Deary IJ
and 1 more — show all
McIntosh AM
Molecular psychiatry · 2017 · PMID 28937693 · open access

Questions about rs145452708

What is rs145452708?

rs145452708 is a single position in the genome, in or near the ADH1B gene. Published research associates it with alcohol consumption. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs145452708 linked to?

On MyGeneLog this position is linked to Alcohol Consumption. The research behind each link, and its sources, are set out on that condition page.

Does having rs145452708 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs145452708 come from?

GWAS Catalog, Mol Psychiatry 2017, PMID:28937693. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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