near HLA-DQA1 · rs145380601
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
Its strongest genetic-study result is p = 10−11, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 18,750 African American or Afro-Caribbean cases, 89,354 African American or Afro-Caribbean controls, 5,910 Hispanic or Latin American cases, 48,894 Hispanic or Latin American controls, 359 East Asian ancestry cases, 6,129 East Asian ancestry controls, 65,194 European ancestry cases, 340,272 European ancestry controls.
The effect Each copy of the C allele shifted the measure 0.106 lower (95% confidence interval 0.079-0.133); p = 1 × 10−11.
How common The C allele had a frequency of about 85% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — between genes, 4.1 kb from HLA-DQA1.
rs145380601 is a single position in the genome, in or near the near HLA-DQA1 gene. Published research associates it with edema (phecode 782.3). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Edema (PheCode 782.3) (rs145380601). MyGeneLog™. https://www.mygenelog.com/variants/rs145380601