Standard
Fasting glucose
SPC25 · rs145353824
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 9,343 South Asian ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0766 higher; p = 2 × 10−11.
How common The A allele had a frequency of about 97% in the people studied.
Where it sits Chromosome 2, band 2q31.1 — in the 3′ untranslated region of G6PC2.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Fasting glucose compared to the general population.
A/C
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Fasting glucose.
C/C
Published research associates this genotype with typical/baseline likelihood of Fasting glucose — no copies of the reported risk allele.
Source
The trans-ancestral genomic architecture of glycemic traits
Chen J,
Spracklen CN,
Marenne G,
Varshney A,
Corbin LJ,
Luan J,
Willems SM,
Wu Y,
Zhang X,
Horikoshi M,
Boutin TS,
Mägi R
and 393 more — show all
Waage J,
Li-Gao R,
Chan KHK,
Yao J,
Anasanti MD,
Chu AY,
Claringbould A,
Heikkinen J,
Hong J,
Hottenga JJ,
Huo S,
Kaakinen MA,
Louie T,
März W,
Moreno-Macias H,
Ndungu A,
Nelson SC,
Nolte IM,
North KE,
Raulerson CK,
Ray D,
Rohde R,
Rybin D,
Schurmann C,
Sim X,
Southam L,
Stewart ID,
Wang CA,
Wang Y,
Wu P,
Zhang W,
Ahluwalia TS,
Appel EVR,
Bielak LF,
Brody JA,
Burtt NP,
Cabrera CP,
Cade BE,
Chai JF,
Chai X,
Chang LC,
Chen CH,
Chen BH,
Chitrala KN,
Chiu YF,
de Haan HG,
Delgado GE,
Demirkan A,
Duan Q,
Engmann J,
Fatumo SA,
Gayán J,
Giulianini F,
Gong JH,
Gustafsson S,
Hai Y,
Hartwig FP,
He J,
Heianza Y,
Huang T,
Huerta-Chagoya A,
Hwang MY,
Jensen RA,
Kawaguchi T,
Kentistou KA,
Kim YJ,
Kleber ME,
Kooner IK,
Lai S,
Lange LA,
Langefeld CD,
Lauzon M,
Li M,
Ligthart S,
Liu J,
Loh M,
Long J,
Lyssenko V,
Mangino M,
Marzi C,
Montasser ME,
Nag A,
Nakatochi M,
Noce D,
Noordam R,
Pistis G,
Preuss M,
Raffield L,
Rasmussen-Torvik LJ,
Rich SS,
Robertson NR,
Rueedi R,
Ryan K,
Sanna S,
Saxena R,
Schraut KE,
Sennblad B,
Setoh K,
Smith AV,
Sparsø T,
Strawbridge RJ,
Takeuchi F,
Tan J,
Trompet S,
van den Akker E,
van der Most PJ,
Verweij N,
Vogel M,
Wang H,
Wang C,
Wang N,
Warren HR,
Wen W,
Wilsgaard T,
Wong A,
Wood AR,
Xie T,
Zafarmand MH,
Zhao JH,
Zhao W,
Amin N,
Arzumanyan Z,
Astrup A,
Bakker SJL,
Baldassarre D,
Beekman M,
Bergman RN,
Bertoni A,
Blüher M,
Bonnycastle LL,
Bornstein SR,
Bowden DW,
Cai Q,
Campbell A,
Campbell H,
Chang YC,
de Geus EJC,
Dehghan A,
Du S,
Eiriksdottir G,
Farmaki AE,
Frånberg M,
Fuchsberger C,
Gao Y,
Gjesing AP,
Goel A,
Han S,
Hartman CA,
Herder C,
Hicks AA,
Hsieh CH,
Hsueh WA,
Ichihara S,
Igase M,
Ikram MA,
Johnson WC,
Jørgensen ME,
Joshi PK,
Kalyani RR,
Kandeel FR,
Katsuya T,
Khor CC,
Kiess W,
Kolcic I,
Kuulasmaa T,
Kuusisto J,
Läll K,
Lam K,
Lawlor DA,
Lee NR,
Lemaitre RN,
Li H,
Lin SY,
Lindström J,
Linneberg A,
Liu J,
Lorenzo C,
Matsubara T,
Matsuda F,
Mingrone G,
Mooijaart S,
Moon S,
Nabika T,
Nadkarni GN,
Nadler JL,
Nelis M,
Neville MJ,
Norris JM,
Ohyagi Y,
Peters A,
Peyser PA,
Polasek O,
Qi Q,
Raven D,
Reilly DF,
Reiner A,
Rivideneira F,
Roll K,
Rudan I,
Sabanayagam C,
Sandow K,
Sattar N,
Schürmann A,
Shi J,
Stringham HM,
Taylor KD,
Teslovich TM,
Thuesen B,
Timmers PRHJ,
Tremoli E,
Tsai MY,
Uitterlinden A,
van Dam RM,
van Heemst D,
van Hylckama Vlieg A,
van Vliet-Ostaptchouk JV,
Vangipurapu J,
Vestergaard H,
Wang T,
Willems van Dijk K,
Zemunik T,
Abecasis GR,
Adair LS,
Aguilar-Salinas CA,
Alarcón-Riquelme ME,
An P,
Aviles-Santa L,
Becker DM,
Beilin LJ,
Bergmann S,
Bisgaard H,
Black C,
Boehnke M,
Boerwinkle E,
Böhm BO,
Bønnelykke K,
Boomsma DI,
Bottinger EP,
Buchanan TA,
Canouil M,
Caulfield MJ,
Chambers JC,
Chasman DI,
Chen YI,
Cheng CY,
Collins FS,
Correa A,
Cucca F,
de Silva HJ,
Dedoussis G,
Elmståhl S,
Evans MK,
Ferrannini E,
Ferrucci L,
Florez JC,
Franks PW,
Frayling TM,
Froguel P,
Gigante B,
Goodarzi MO,
Gordon-Larsen P,
Grallert H,
Grarup N,
Grimsgaard S,
Groop L,
Gudnason V,
Guo X,
Hamsten A,
Hansen T,
Hayward C,
Heckbert SR,
Horta BL,
Huang W,
Ingelsson E,
James PS,
Jarvelin MR,
Jonas JB,
Jukema JW,
Kaleebu P,
Kaplan R,
Kardia SLR,
Kato N,
Keinanen-Kiukaanniemi SM,
Kim BJ,
Kivimaki M,
Koistinen HA,
Kooner JS,
Körner A,
Kovacs P,
Kuh D,
Kumari M,
Kutalik Z,
Laakso M,
Lakka TA,
Launer LJ,
Leander K,
Li H,
Lin X,
Lind L,
Lindgren C,
Liu S,
Loos RJF,
Magnusson PKE,
Mahajan A,
Metspalu A,
Mook-Kanamori DO,
Mori TA,
Munroe PB,
Njølstad I,
O'Connell JR,
Oldehinkel AJ,
Ong KK,
Padmanabhan S,
Palmer CNA,
Palmer ND,
Pedersen O,
Pennell CE,
Porteous DJ,
Pramstaller PP,
Province MA,
Psaty BM,
Qi L,
Raffel LJ,
Rauramaa R,
Redline S,
Ridker PM,
Rosendaal FR,
Saaristo TE,
Sandhu M,
Saramies J,
Schneiderman N,
Schwarz P,
Scott LJ,
Selvin E,
Sever P,
Shu XO,
Slagboom PE,
Small KS,
Smith BH,
Snieder H,
Sofer T,
Sørensen TIA,
Spector TD,
Stanton A,
Steves CJ,
Stumvoll M,
Sun L,
Tabara Y,
Tai ES,
Timpson NJ,
Tönjes A,
Tuomilehto J,
Tusie T,
Uusitupa M,
van der Harst P,
van Duijn C,
Vitart V,
Vollenweider P,
Vrijkotte TGM,
Wagenknecht LE,
Walker M,
Wang YX,
Wareham NJ,
Watanabe RM,
Watkins H,
Wei WB,
Wickremasinghe AR,
Willemsen G,
Wilson JF,
Wong TY,
Wu JY,
Xiang AH,
Yanek LR,
Yengo L,
Yokota M,
Zeggini E,
Zheng W,
Zonderman AB,
Rotter JI,
Gloyn AL,
McCarthy MI,
Dupuis J,
Meigs JB,
Scott RA,
Prokopenko I,
Leong A,
Liu CT,
Parker SCJ,
Mohlke KL,
Langenberg C,
Wheeler E,
Morris AP,
Barroso I
Nature genetics · 2021 · PMID 34059833 · open access
Questions about rs145353824
What is rs145353824?
rs145353824 is a single position in the genome, in or near the SPC25 gene. Published research associates it with fasting glucose. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs145353824 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs145353824 come from?
GWAS Catalog, Nature genetics 2021, PMID:34059833. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Fasting glucose (rs145353824). MyGeneLog™. https://www.mygenelog.com/variants/rs145353824
← See all variants