Sclerosing cholangitis and ulcerative colitis (combined)
TCF4 · rs1452787
1 525318223226Reads by AI crawlersClaude5ChatGPT3Google · Gemini0Perplexity1Meta AI8Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others26Total52Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied Up to 389 European ancestry primary sclerosing cholangitis cases, 987 European ancestry ulcerative colitis cases, 2,968 European ancestry controls; replicated in 1,012 European ancestry primary sclerosing cholangitis cases, 4,444 European ancestry ulcerative colitis cases, 11,659 European ancestry controls.
The effect
Each copy of the A allele carried 1.33 times the odds of Sclerosing cholangitis and ulcerative colitis (combined) (95% confidence interval 1.20-1.47); p = 3 × 10−8.
How common The A allele had a frequency of about 72% in the people studied.
Where it sits Chromosome 18, band 18q21.2 — in an intron of TCF4.
What each result means
A/ATwo copies of the version the research linked to Sclerosing cholangitis and ulcerative colitis (combined). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Sclerosing cholangitis and ulcerative colitis (combined). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Sclerosing cholangitis and ulcerative colitis (combined). This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs1452787
What is rs1452787?
rs1452787 is a single position in the genome, in or near the TCF4 gene. Published research associates it with sclerosing cholangitis and ulcerative colitis (combined). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1452787 linked to?
On MyGeneLog this position is linked to Ulcerative Colitis, Post-Traumatic Stress Disorder (PTSD). The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs1452787?
Subjects that appear in the title or abstract of the same papers as this rsID include short-sightedness and screens (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs1452787 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1452787 come from?
GWAS Catalog, Hepatology 2012, PMID:22821403. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 525318223226Reads by AI crawlersClaude5ChatGPT3Google · Gemini0Perplexity1Meta AI8Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others26Total52Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Sclerosing cholangitis and ulcerative colitis (combined) (rs1452787). MyGeneLog™. https://www.mygenelog.com/variants/rs1452787