Standard

Diastolic blood pressure x depressive symptoms (quantitative) interaction (1df test)

near UBE2K · rs145132348

Where this position leads

What the study found

Who was studied 19,756 African American or Afro-Caribbean, African ancestry individuals.

The effect Each copy of the C allele shifted the measure 2.92 higher (95% confidence interval 1.92-3.92); p = 1 × 10⁻⁸.

How common The C allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 4, band 4p14 — between genes, 8.5 kb from UBE2K.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Diastolic blood pressure x depressive symptoms (quantitative) interaction (1df test) compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Diastolic blood pressure x depressive symptoms (quantitative) interaction (1df test).

T/T Published research associates this genotype with typical/baseline likelihood of Diastolic blood pressure x depressive symptoms (quantitative) interaction (1df test) — no copies of the reported risk allele.

Source

Large-scale blood pressure GWAS accounting for gene-depression interactions in 564,680 individuals from diverse populations

Lee S, Miller CL, Bentley AR, Brown MR, Nagarajan P, Noordam R, Morrison JL, Schwander K, Westerman K, Kho M, Kraja AT, de Vries PS

and 137 more — show all

Ammous F, Aschard H, Bartz TM, Do A, Dupont CT, Feitosa MF, Gudmundsdottir V, Guo X, Harris SE, Hikino K, Huang Z, Lefevre C, Lyytikäinen LP, Milaneschi Y, Nardone GG, Santin A, Schmidt H, Shen B, Sofer T, Sun Q, Tan YA, Tang J, Thériault S, van der Most PJ, Ware EB, Weiss S, Xing WY, Yu C, Zhao W, Ansari MAY, Anugu P, Attia JR, Bazzano LA, Bis JC, Breyer M, Cade B, Chen G, Collins S, Corley J, Davies G, Dörr M, Du J, Edwards TL, Faquih T, Faul JD, Fohner AE, Fretts AM, Gangireddy S, Gepner A, Graff M, Hofer E, Homuth G, Hood MM, Jie X, Kähönen M, Kardia SLR, Karvonen-Gutierrez CA, Launer LJ, Levy D, Maheshwari M, Martin LW, Matsuda K, McNeil JJ, Nolte IM, Okochi T, Raffield LM, Raitakari OT, Risch L, Risch M, Roux AD, Ruiz-Narvaez EA, Russ TC, Saito T, Schreiner PJ, Scott RJ, Shikany J, Smith JA, Snieder H, Spedicati B, Tai ES, Taylor AM, Taylor KD, Tesolin P, van Dam RM, Wang R, Wenbin W, Xie T, Yao J, Young KL, Zhang R, Zonderman AB, Concas MP, Conen D, Cox SR, Evans MK, Fox ER, de Las Fuentes L, Giri A, Girotto G, Grabe HJ, Gu C, Gudnason V, Harlow SD, Holliday E, Jost JB, Lacaze P, Lee S, Lehtimäki T, Li C, Liu CT, Morrison AC, North KE, Penninx BWJH, Peyser PA, Province MM, Psaty BM, Redline S, Rosendaal FR, Rotimi CN, Rotter JI, Schmidt R, Sim X, Terao C, Weir DR, Zhu X, Franceschini N, O'Connell JR, Jaquish CE, Wang H, Manning A, Munroe PB, Rao DC, Chen H, Gauderman WJ, Bierut LJ, Winkler TW, Fornage M

Biobank Japan Project · Lifelines Cohort Study,

HGG advances · 2026 · PMID 41520179 · open access

Questions about rs145132348

What is rs145132348?

rs145132348 is a single position in the genome, in or near the near UBE2K gene. Published research associates it with diastolic blood pressure x depressive symptoms (quantitative) interaction (1df test). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs145132348 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs145132348 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs145132348 come from?

GWAS Catalog, HGG advances 2026, PMID:41520179. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Diastolic blood pressure x depressive symptoms (quantitative) interaction (1df test) (rs145132348). MyGeneLog™. https://www.mygenelog.com/variants/rs145132348

← See all variants