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Who was studied up to 60,465 European ancestry individuals, up to 2,568 East Asian ancestry individuals, up to 3,271 African American individuals, up to 1,435 Hispanic individuals.
The effect
Each copy of the A allele shifted the measure 0.308 lower; p = 8 × 10−15.
How common The A allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 16, band 16q23.3 — a missense change in SLC38A8.
What ClinVar records
ClassificationConflicting classifications of pathogenicity; criteria provided, conflicting classifications (1 of 4 stars, 2 submitters), last evaluated 2025-10-28.
ClinVar record 2061370NM_001080442.3(SLC38A8):c.170C>T (p.Pro57Leu)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the version the research linked to Adiponectin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Adiponectin levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Adiponectin levels. This is the starting point the study compared everyone against.
American journal of human genetics · 2019 · PMID 31178129
Questions about rs145119400
What is rs145119400?
rs145119400 is a single position in the genome, in or near the SLC38A8 gene. Published research associates it with adiponectin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs145119400 linked to?
On MyGeneLog this position is linked to Adiponectin Levels. The research behind each link, and its sources, are set out on that condition page.
Does having rs145119400 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs145119400 come from?
GWAS Catalog, American journal of human genetics 2019, PMID:31178129. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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