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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 276 African American or Afro-Caribbean cases, 120,756 African American or Afro-Caribbean controls, 1,013 European ancestry cases, 446,704 European ancestry controls.
The effect
Each copy of the G allele shifted the measure 2.94 lower (95% confidence interval 2.91-2.97); p = 4 × 10−11.
How common The G allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 9, band 9p21.1 — a missense change in TAF1L.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Lower gastrointestinal congenital anomalies (PheCode 750.2) — no copies of the reported risk allele.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lower gastrointestinal congenital anomalies (PheCode 750.2).
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lower gastrointestinal congenital anomalies (PheCode 750.2) compared to the general population.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs145062474
What is rs145062474?
rs145062474 is a single position in the genome, in or near the TAF1L gene. Published research associates it with lower gastrointestinal congenital anomalies (phecode 750.2). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs145062474 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs145062474 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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