Sensitive

Alzheimer disease and age of onset

SDR42E2 · rs145049847

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Alzheimer disease and age of onset compared to the general population. (GWAS Catalog, Mol Psychiatry 2016, PMID:26830138)

C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Alzheimer disease and age of onset. (GWAS Catalog, Mol Psychiatry 2016, PMID:26830138)

G/G Published research associates this genotype with typical/baseline likelihood of Alzheimer disease and age of onset — no copies of the reported risk allele. (GWAS Catalog, Mol Psychiatry 2016, PMID:26830138)

Source: GWAS Catalog, Mol Psychiatry 2016, PMID:26830138

Questions about rs145049847

What is rs145049847?

rs145049847 is a single position in the genome, in or near the SDR42E2 gene. Published research associates it with alzheimer disease and age of onset. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs145049847 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs145049847 come from?

GWAS Catalog, Mol Psychiatry 2016, PMID:26830138. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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