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Who was studied 5,602 European ancestry cases, 21,120 European ancestry controls.
The effect
Each copy of the A allele carried 1.91 times the odds of Acne (severe) (95% confidence interval 1.60-2.28); p = 5 × 10−13.
How common The A allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 11, band 11q13.1 — between genes, 1.7 kb from NAALADL1.
What each result means
A/ATwo copies of the version the research linked to Acne (severe). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Acne (severe). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Acne (severe). This is the starting point the study compared everyone against.
Nature communications · 2018 · PMID 30542056 · open access
Questions about rs144991069
What is rs144991069?
rs144991069 is a single position in the genome, in or near the OVOL1 gene. Published research associates it with acne (severe). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs144991069 linked to?
On MyGeneLog this position is linked to Severe Acne. The research behind each link, and its sources, are set out on that condition page.
Does having rs144991069 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs144991069 come from?
GWAS Catalog, Nature communications 2018, PMID:30542056. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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