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Eye color

HERC2 · rs144864205

Where this position leads

Condition: Eye Color and Pigmentation

rs144864205 Condition: Eye Color and Pigmentation Eye Color and Pigmentation Condition rs144864205 rs144864205 HERC2

What the study found

Who was studied 4,987 Iberian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.616 higher (95% confidence interval 0.45-0.78); p = 7 × 10−13.

How common The A allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 15, band 15q13.1 — in an intron of HERC2.

What each result means

A/A Two copies of the version the research linked to Eye color. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Eye color. That is a smaller link than two copies.
G/G No copy of the version the research linked to Eye color. This is the starting point the study compared everyone against.
Source
Skin Phototype and Disease: A Comprehensive Genetic Approach to Pigmentary Traits Pleiotropy Using PRS in the GCAT Cohort
Farré X, Blay N, Cortés B, Carreras A, Iraola-Guzmán S, de Cid R
Genes · 2023 · PMID 36672889 · open access

Questions about rs144864205

What is rs144864205?

rs144864205 is a single position in the genome, in or near the HERC2 gene. Published research associates it with eye color. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs144864205 linked to?

On MyGeneLog this position is linked to Eye Color and Pigmentation. The research behind each link, and its sources, are set out on that condition page.

Does having rs144864205 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs144864205 come from?

GWAS Catalog, Genes 2023, PMID:36672889. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Eye color (rs144864205). MyGeneLog™. https://www.mygenelog.com/variants/rs144864205

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