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Lung function (FVC)

FGF10 · rs1448044

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 60,749 European ancestry individuals, 7,721 African ancestry individuals; replicated in 111,556 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 6.69 higher; p = 2 × 10⁻¹¹.

How common The A allele had a frequency of about 36% in the people studied.

Where it sits Chromosome 5, band 5p12 — between genes, 3.4 kb from FGF10.

What each result means

A/A Two copies of the version the research linked to Lung function (FVC). That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Lung function (FVC). That is a smaller link than two copies.

G/G No copy of the version the research linked to Lung function (FVC). This is the starting point the study compared everyone against.

Source

Meta-analysis of exome array data identifies six novel genetic loci for lung function

Jackson VE, Latourelle JC, Wain LV, Smith AV, Grove ML, Bartz TM, Obeidat M, Province MA, Gao W, Qaiser B, Porteous DJ, Cassano PA

and 95 more — show all

Ahluwalia TS, Grarup N, Li J, Altmaier E, Marten J, Harris SE, Manichaikul A, Pottinger TD, Li-Gao R, Lind-Thomsen A, Mahajan A, Lahousse L, Imboden M, Teumer A, Prins B, Lyytikäinen LP, Eiriksdottir G, Franceschini N, Sitlani CM, Brody JA, Bossé Y, Timens W, Kraja A, Loukola A, Tang W, Liu Y, Bork-Jensen J, Justesen JM, Linneberg A, Lange LA, Rawal R, Karrasch S, Huffman JE, Smith BH, Davies G, Burkart KM, Mychaleckyj JC, Bonten TN, Enroth S, Lind L, Brusselle GG, Kumar A, Stubbe B, Kähönen M, Wyss AB, Psaty BM, Heckbert SR, Hao K, Rantanen T, Kritchevsky SB, Lohman K, Skaaby T, Pisinger C, Hansen T, Schulz H, Polasek O, Campbell A, Starr JM, Rich SS, Mook-Kanamori DO, Johansson Å, Ingelsson E, Uitterlinden AG, Weiss S, Raitakari OT, Gudnason V, North KE, Gharib SA, Sin DD, Taylor KD, O'Connor GT, Kaprio J, Harris TB, Pederson O, Vestergaard H, Wilson JG, Strauch K, Hayward C, Kerr S, Deary IJ, Barr RG, de Mutsert R, Gyllensten U, Morris AP, Ikram MA, Probst-Hensch N, Gläser S, Zeggini E, Lehtimäki T, Strachan DP, Dupuis J, Morrison AC, Hall IP, Tobin MD, London SJ

Understanding Society Scientific Group

Wellcome open research · 2018 · PMID 30175238 · open access

Questions about rs1448044

What is rs1448044?

rs1448044 is a single position in the genome, in or near the FGF10 gene. Published research associates it with lung function (fvc). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1448044 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1448044 come from?

GWAS Catalog, Wellcome open research 2018, PMID:30175238. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Lung function (FVC) (rs1448044). MyGeneLog™. https://www.mygenelog.com/variants/rs1448044

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