Sensitive

Parkinson's disease or first degree relation to individual with Parkinson's disease

GXYLT1 · rs144755950

Where this position leads

Condition: Parkinson's Disease

rs144755950 Condition: Parkinson's Disease Parkinson's Disease Condition rs144755950 rs144755950 GXYLT1

What the study found

Who was studied 15,056 European ancestry cases, 18,618 European ancestry proxy cases, 449,056 European ancestry controls; replicated in 22,632 European ancestry cases, 968,735 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.399 lower (95% confidence interval 0.28-0.52); p = 2 × 10−10.

How common The T allele had a frequency of about 99% in the people studied.

Where it sits Chromosome 12, band 12q12 — in an intron of GXYLT1.

What each result means

C/C No copy of the version the research linked to Parkinson's disease or first degree relation to individual with Parkinson's disease. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Parkinson's disease or first degree relation to individual with Parkinson's disease. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Parkinson's disease or first degree relation to individual with Parkinson's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs144755950

What is rs144755950?

rs144755950 is a single position in the genome, in or near the GXYLT1 gene. Published research associates it with parkinson's disease or first degree relation to individual with parkinson's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs144755950 linked to?

On MyGeneLog this position is linked to Parkinson's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs144755950 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs144755950 come from?

GWAS Catalog, Lancet Neurol 2019, PMID:31701892. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Parkinson's disease or first degree relation to individual with Parkinson's disease (rs144755950). MyGeneLog™. https://www.mygenelog.com/variants/rs144755950

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