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Remission after SSRI treatment in MDD or neuroticism

PLEKHM1 · rs144733372

Where this position leads

Condition: Neuroticism

rs144733372 Condition: Neuroticism Neuroticism Condition rs144733372 rs144733372 PLEKHM1

What the study found

Who was studied 865 individuals with SSRI response data, 170,911 individuals with personality trait data.

The effect The reported allele is G; the catalogue records no effect size ; p = 3 × 10−11.

Where it sits Chromosome 17, band 17q21.31 — in an intron of PLEKHM1.

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Remission after SSRI treatment in MDD or neuroticism compared to the general population.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Remission after SSRI treatment in MDD or neuroticism.
T/T Published research associates this genotype with typical/baseline likelihood of Remission after SSRI treatment in MDD or neuroticism — no copies of the reported risk allele.
Source
Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder
Amare AT, Schubert KO, Tekola-Ayele F, Hsu YH, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J
and 25 more — show all
Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Kato M, Liu YL, Praphanphoj V, Stingl JC, Bobo WV, Tsai SJ, Kubo M, Klein TE, Weinshilboum RM, Biernacka JM, Baune BT
Frontiers in psychiatry · 2018 · PMID 29559929 · open access

Questions about rs144733372

What is rs144733372?

rs144733372 is a single position in the genome, in or near the PLEKHM1 gene. Published research associates it with remission after ssri treatment in mdd or neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs144733372 linked to?

On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.

Does having rs144733372 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs144733372 come from?

GWAS Catalog, Front Psychiatry 2018, PMID:29559929. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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