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Nicotine dependence symptom count

RRAGAP1-AS1 · rs144667340

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 3,529 African American individuals, 4,117 European American individuals.

The effect The reported allele is T; the catalogue records no effect size ; p = 3 × 10⁻¹⁰.

Where it sits Chromosome 14, band 14q21.2 — in an intron of RRAGAP1-AS1.

What each result means

G/G Published research associates this genotype with typical/baseline likelihood of Nicotine dependence symptom count — no copies of the reported risk allele.

G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Nicotine dependence symptom count.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Nicotine dependence symptom count compared to the general population.

Source

Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans

Gelernter J, Kranzler HR, Sherva R, Almasy L, Herman AI, Koesterer R, Zhao H, Farrer LA

Biological psychiatry · 2015 · PMID 25555482

Questions about rs144667340

What is rs144667340?

rs144667340 is a single position in the genome, in or near the RRAGAP1-AS1 gene. Published research associates it with nicotine dependence symptom count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs144667340 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs144667340 come from?

GWAS Catalog, Biological psychiatry 2015, PMID:25555482. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Nicotine dependence symptom count (rs144667340). MyGeneLog™. https://www.mygenelog.com/variants/rs144667340

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