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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 235,096 European ancestry males.
The effect
Each copy of the G allele shifted the measure 0.021 lower (95% confidence interval 0.015-0.027); p = 3 × 10−11.
How common The G allele had a frequency of about 21% in the people studied.
Where it sits Chromosome 8, band 8q21.13 — between genes, 26.7 kb from PAG1.
What each result means
A/ANo copy of the version the research linked to Testosterone levels. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Testosterone levels. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Testosterone levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 40229599 · open access
Questions about rs1445566
What is rs1445566?
rs1445566 is a single position in the genome, in or near the near PAG1 gene. Published research associates it with testosterone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1445566 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1445566 come from?
GWAS Catalog, Nature genetics 2025, PMID:40229599. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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