0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 46,213 European ancestry individuals, 11,787 African American individuals; replicated in 31,854 European ancestry individuals, 1,937 individuals.
The effect
Each copy of the T allele shifted the measure 0.079 higher (95% confidence interval 0.052-0.106); p = 4 × 10−8.
Where it sits Chromosome 2, band 2p13.3 — in an intron of ARHGAP25.
What each result means
C/CNo copy of the version the research linked to Nicotine dependence. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Nicotine dependence. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Nicotine dependence. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2020 · PMID 33144568 · open access
Questions about rs144481999
What is rs144481999?
rs144481999 is a single position in the genome, in or near the ARHGAP25 gene. Published research associates it with nicotine dependence. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs144481999 linked to?
On MyGeneLog this position is linked to Smoking Behaviour and Nicotine Dependence. The research behind each link, and its sources, are set out on that condition page.
Does having rs144481999 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs144481999 come from?
GWAS Catalog, Nature communications 2020, PMID:33144568. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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