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TP53I3 protein levels

FAM228B · rs144231256

Where this position leads

Condition: Celiac Disease

rs144231256 Condition: Celiac Disease Celiac Disease Condition rs144231256 rs144231256 FAM228B

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.454 lower (95% confidence interval 0.32-0.59); p = 7 × 10−12.

How common The T allele had a frequency of about 0% in the people studied.

Where it sits Chromosome 2, band 2p23.3 — a synonymous change in FAM228B.

What each result means

C/C No copy of the version the research linked to TP53I3 protein levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to TP53I3 protein levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to TP53I3 protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs144231256

What is rs144231256?

rs144231256 is a single position in the genome, in or near the FAM228B gene. Published research associates it with tp53i3 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs144231256 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs144231256 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs144231256 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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TP53I3 protein levels (rs144231256). MyGeneLog™. https://www.mygenelog.com/variants/rs144231256

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