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Systolic blood pressure response to thiazide and thiazide-like diuretics in hypertension

RAB9BP1 · rs1442118

Where this position leads

Condition: Blood Pressure

rs1442118 Condition: Blood Pressure Blood Pressure Condition rs1442118 rs1442118 RAB9BP1

What the study found

Who was studied 290 African American individuals, 397 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 3.89 higher; p = 2 × 10−8.

Where it sits Chromosome 5, band 5q21.2 — in an intron of NIHCOLE.

What each result means

A/A Two copies of the version the research linked to Systolic blood pressure response to thiazide and thiazide-like diuretics in hypertension. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Systolic blood pressure response to thiazide and thiazide-like diuretics in hypertension. That is a smaller link than two copies.
G/G No copy of the version the research linked to Systolic blood pressure response to thiazide and thiazide-like diuretics in hypertension. This is the starting point the study compared everyone against.
Source

Questions about rs1442118

What is rs1442118?

rs1442118 is a single position in the genome, in or near the RAB9BP1 gene. Published research associates it with systolic blood pressure response to thiazide and thiazide-like diuretics in hypertension. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1442118 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs1442118 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1442118 come from?

GWAS Catalog, Scientific reports 2019, PMID:31754133. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Systolic blood pressure response to thiazide and thiazide-like diuretics in hypertension (rs1442118). MyGeneLog™. https://www.mygenelog.com/variants/rs1442118

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