Standard

CD33 protein levels

SIGLEC20P · rs144092860

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.396 lower (95% confidence interval 0.32-0.47); p = 2 × 10⁻³⁸.

How common The A allele had a frequency of about 0% in the people studied.

Where it sits Chromosome 19, band 19q13.41 — in an intron of SIGLEC20P.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of CD33 protein levels compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with CD33 protein levels.

G/G Published research associates this genotype with typical/baseline likelihood of CD33 protein levels — no copies of the reported risk allele.

Source

A scalable variational inference approach for increased mixed-model association power

Loya H, Kalantzis G, Cooper F, Palamara PF

Nature genetics · 2025 · PMID 39789286 · open access

Questions about rs144092860

What is rs144092860?

rs144092860 is a single position in the genome, in or near the SIGLEC20P gene. Published research associates it with cd33 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs144092860 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs144092860 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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CD33 protein levels (rs144092860). MyGeneLog™. https://www.mygenelog.com/variants/rs144092860

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