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Kidney cortex volume

near REST · rs143898047

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁸, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 38,816 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.07 lower (95% confidence interval 0.05-0.09); p = 3 × 10⁻⁸.

How common The G allele had a frequency of about 92% in the people studied.

Where it sits Chromosome 4, band 4q12 — between genes, 21.5 kb from REST.

How common each version is

AG

Korean KRGDB

A 7.9% · G 92.1%

Korean Korea4K

A 7.2% · G 92.8%

Korean Korea1K

A 7.5% · G 92.5%

Japanese ToMMo

A 10.5% · G 89.5%

World gnomAD

A 7.6% · G 92.4%

World 1000 Genomes

A 6.7% · G 93.3%

World TOPMed

A 7.5% · G 92.5%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A No copy of the version the research linked to Kidney cortex volume. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Kidney cortex volume. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Kidney cortex volume. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genetic screens of imaging-derived kidney volumes identify genes linked to kidney function

Monteiro-Martins S, Li Y, Borisov O, Khan A, Reichardt W, Haug S, Kellner E, Buechert M, Ott E, Russe MF, Bamberg F, Kiryluk K

and 3 more — show all

Sekula P, Reisert M, Köttgen A

Kidney international · 2026 · PMID 41077127 · open access

Questions about rs143898047

What is rs143898047?

rs143898047 is a single position in the genome, in or near the near REST gene. Published research associates it with kidney cortex volume. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs143898047 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs143898047 come from?

GWAS Catalog, Kidney international 2026, PMID:41077127. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Kidney cortex volume (rs143898047). MyGeneLog™. https://www.mygenelog.com/variants/rs143898047

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