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Red cell distribution width

PLD1 · rs143845082

Where this position leads

What the study found

Who was studied 116,666 British ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.217 higher (95% confidence interval 0.15-0.28); p = 5 × 10⁻¹³.

How common The A allele had a frequency of about 0% in the people studied.

Where it sits Chromosome 3, band 3q26.31 — a missense change in PLD1.

What ClinVar records

Classification Benign for PLD1-related disorder; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 4 submitters), last evaluated 2026-04-01. ClinVar record 74954 NM_002662.5(PLD1):c.1192C>T (p.Arg398Cys)

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to Red cell distribution width. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Red cell distribution width. That is a smaller link than two copies.

G/G No copy of the version the research linked to Red cell distribution width. This is the starting point the study compared everyone against.

Source

Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers

Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo CL, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, Murray A

and 6 more — show all

Weedon MN, Harries LW, Kuchel GA, Ferrucci L, Frayling TM, Melzer D

PloS one · 2017 · PMID 28957414 · open access

Questions about rs143845082

What is rs143845082?

rs143845082 is a single position in the genome, in or near the PLD1 gene. Published research associates it with red cell distribution width. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs143845082 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs143845082 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs143845082 come from?

GWAS Catalog, PLoS One 2017, PMID:28957414. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Red cell distribution width (rs143845082). MyGeneLog™. https://www.mygenelog.com/variants/rs143845082

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