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Who was studied at least 60,620 European ancestry cases, at least 970,216 European ancestry controls (MTAG boosted by 455,258 Alzheimer's disease samples).
The effect
Each copy of the T allele shifted the measure 0.0227 higher (95% confidence interval 0.016-0.029); p = 4 × 10−11.
Where it sits Chromosome 5, band 5q31.2 — in an intron of CDC25C.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Atrial fibrillation (MTAG) — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Atrial fibrillation (MTAG).
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Atrial fibrillation (MTAG) compared to the general population.
Nature communications · 2024 · PMID 39537608 · open access
Questions about rs143731384
What is rs143731384?
rs143731384 is a single position in the genome, in or near the CDC25C gene. Published research associates it with atrial fibrillation (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs143731384 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs143731384 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs143731384 come from?
GWAS Catalog, Nature communications 2024, PMID:39537608. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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