Sensitive

Attention deficit hyperactivity disorder

SEMA6D · rs1435746

Where this position leads

Condition: ADHD (Attention Deficit Hyperactivity Disorder)

What the study found

Who was studied 299,017 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.016 lower (95% confidence interval 0.01-0.022); p = 9 × 10⁻⁹.

How common The A allele had a frequency of about 53% in the people studied.

Where it sits Chromosome 15, band 15q21.1 — in an intron of SEMA6D.

What each result means

A/A Two copies of the version the research linked to Attention deficit hyperactivity disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Attention deficit hyperactivity disorder. That is a smaller link than two copies.

G/G No copy of the version the research linked to Attention deficit hyperactivity disorder. This is the starting point the study compared everyone against.

Source

Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes

van der Laan CM, Ip HF, Schipper M, Hottenga JJ, St Pourcain B, Zayats T, Pool R, Krapohl EML, Brikell I, Soler Artigas M, Cabana-Domínguez J, Llonga N

and 117 more — show all

Nolte IM, Bolhuis K, Palviainen T, Zafarmand H, Gordon S, Aliev F, Burt SA, Wang CA, Saunders G, Karhunen V, Adkins DE, Border R, Peterson RE, Prinz JA, Thiering E, Vilor-Tejedor N, Ahluwalia TS, Allegrini A, Rimfeld K, Chen Q, Lu Y, Martin J, Bosch R, Ramos-Quiroga JA, Neumann A, Ensink J, Grasby KL, Morosoli JJ, Tong X, Marrington S, Scott JG, Shabalin AA, Corley R, Evans LM, Sugden K, Alemany S, Sass L, Vinding R, Ehli EA, Hagenbeek FA, Derks EM, Larsson H, Snieder H, Cecil C, Whipp AM, Korhonen T, Vuoksimaa E, Rose RJ, Uitterlinden AG, Haavik J, Harris JR, Helgeland Ø, Johansson S, Knudsen GPS, Njolstad PR, Lu Q, Rodriguez A, Henders AK, Mamun A, Najman JM, Brown S, Hopfer C, Krauter K, Reynolds CA, Smolen A, Stallings M, Wadsworth S, Wall TL, Eaves L, Silberg JL, Miller A, Havdahl A, Llop S, Lopez-Espinosa MJ, Bønnelykke K, Sunyer J, Arseneault L, Standl M, Heinrich J, Boden J, Pearson J, Horwood J, Kennedy M, Poulton R, Maes HH, Hewitt J, Copeland WE, Middeldorp CM, Williams GM, Wray N, Järvelin MR, McGue M, Iacono W, Caspi A, Moffitt TE, Whitehouse AJO, Pennell CE, Klump KL, Jiang C, Dick DM, Reichborn-Kjennerud T, Martin NG, Medland SE, Vrijkotte T, Kaprio J, Tiemeier H, Davey Smith G, Hartman CA, Oldehinkel AJ, Casas M, Ribasés M, Lichtenstein P, Lundström S, Plomin R, Bartels M, Nivard MG, Boomsma DI

Nature genetics · 2025 · PMID 40962958

Questions about rs1435746

What is rs1435746?

rs1435746 is a single position in the genome, in or near the SEMA6D gene. Published research associates it with attention deficit hyperactivity disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1435746 linked to?

On MyGeneLog this position is linked to ADHD (Attention Deficit Hyperactivity Disorder). The research behind each link, and its sources, are set out on that condition page.

Does having rs1435746 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1435746 come from?

GWAS Catalog, Nature genetics 2025, PMID:40962958. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Attention deficit hyperactivity disorder (rs1435746). MyGeneLog™. https://www.mygenelog.com/variants/rs1435746

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