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Smoking initiation (ever regular vs never regular) (MTAG)

TULP4 · rs143465123

Where this position leads

Condition: Smoking Behaviour and Nicotine Dependence

What the study found

Who was studied up to 1,359,002 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0167 lower (95% confidence interval 0.012-0.021); p = 3 × 10⁻¹².

How common The T allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 6, band 6q25.3 — in an intron of TULP4.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Smoking initiation (ever regular vs never regular) (MTAG) — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Smoking initiation (ever regular vs never regular) (MTAG).

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Smoking initiation (ever regular vs never regular) (MTAG) compared to the general population.

Source

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Liu M, Jiang Y, Wedow R, Li Y, Brazel DM, Chen F, Datta G, Davila-Velderrain J, McGuire D, Tian C, Zhan X, Choquet H

and 111 more — show all

Docherty AR, Faul JD, Foerster JR, Fritsche LG, Gabrielsen ME, Gordon SD, Haessler J, Hottenga JJ, Huang H, Jang SK, Jansen PR, Ling Y, Mägi R, Matoba N, McMahon G, Mulas A, Orrù V, Palviainen T, Pandit A, Reginsson GW, Skogholt AH, Smith JA, Taylor AE, Turman C, Willemsen G, Young H, Young KA, Zajac GJM, Zhao W, Zhou W, Bjornsdottir G, Boardman JD, Boehnke M, Boomsma DI, Chen C, Cucca F, Davies GE, Eaton CB, Ehringer MA, Esko T, Fiorillo E, Gillespie NA, Gudbjartsson DF, Haller T, Harris KM, Heath AC, Hewitt JK, Hickie IB, Hokanson JE, Hopfer CJ, Hunter DJ, Iacono WG, Johnson EO, Kamatani Y, Kardia SLR, Keller MC, Kellis M, Kooperberg C, Kraft P, Krauter KS, Laakso M, Lind PA, Loukola A, Lutz SM, Madden PAF, Martin NG, McGue M, McQueen MB, Medland SE, Metspalu A, Mohlke KL, Nielsen JB, Okada Y, Peters U, Polderman TJC, Posthuma D, Reiner AP, Rice JP, Rimm E, Rose RJ, Runarsdottir V, Stallings MC, Stančáková A, Stefansson H, Thai KK, Tindle HA, Tyrfingsson T, Wall TL, Weir DR, Weisner C, Whitfield JB, Winsvold BS, Yin J, Zuccolo L, Bierut LJ, Hveem K, Lee JJ, Munafò MR, Saccone NL, Willer CJ, Cornelis MC, David SP, Hinds DA, Jorgenson E, Kaprio J, Stitzel JA, Stefansson K, Thorgeirsson TE, Abecasis G, Liu DJ, Vrieze S

23andMe Research Team · HUNT All-In Psychiatry

Nature genetics · 2019 · PMID 30643251 · open access

Questions about rs143465123

What is rs143465123?

rs143465123 is a single position in the genome, in or near the TULP4 gene. Published research associates it with smoking initiation (ever regular vs never regular) (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs143465123 linked to?

On MyGeneLog this position is linked to Smoking Behaviour and Nicotine Dependence. The research behind each link, and its sources, are set out on that condition page.

Does having rs143465123 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs143465123 come from?

GWAS Catalog, Nat Genet 2019, PMID:30643251. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Smoking initiation (ever regular vs never regular) (MTAG) (rs143465123). MyGeneLog™. https://www.mygenelog.com/variants/rs143465123

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