0 71213Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot1Amazon2Apple0China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others3Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 6,056 European ancestry cases, 907,977 European ancestry controls, 4,661 East Asian ancestry cases, 354,129 East Asian ancestry controls, 5,450 African, Admixed American, European, East Asian, South Asian or unknown ancestry cases, 1,168,268 African, Admixed American, European, East Asian, South Asian or unknown ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.586 higher (95% confidence interval 0.48-0.7); p = 2 × 10−25.
Where it sits Chromosome 22, band 22q12.1 — in an intron of TTC28.
What each result means
C/CNo copy of the version the research linked to Thyroid cancer. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Thyroid cancer. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Thyroid cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2026 · PMID 42431967 · open access
Questions about rs143459581
What is rs143459581?
rs143459581 is a single position in the genome, in or near the TTC28 gene. Published research associates it with thyroid cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs143459581 linked to?
On MyGeneLog this position is linked to Thyroid Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs143459581 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs143459581 come from?
GWAS Catalog, Nature communications 2026, PMID:42431967. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 71213Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot1Amazon2Apple0China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others3Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Thyroid cancer (rs143459581). MyGeneLog™. https://www.mygenelog.com/variants/rs143459581